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    1. Companies
    2. SPRB
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    Spruce Biosciences, Inc.

    SPRB
    NASDAQ
    Healthcare
    Biotechnology
    Daly City, CA, US20 employeessprucebiosciences.com
    $71.00
    +1.47(2.11%)

    Mkt Cap $41M

    $4.50
    $182.60

    52-Week Range

    At a Glance

    AI-generated

    Spruce Biosciences, Inc.

    8-K
    Spruce Biosciences entered a Termination Agreement with Kaken Pharmaceutical on March 16, 2026, to mutually terminate the January 5, 2023 Collaboration Agreement for tildacerfont in Japan effective March 31, 2026, ending all licenses, rights, and future milestone payments or royalties with no penalties. The company reported full year 2025 financial results including net loss of $39.0 million and cash of $48.9 million.

    $41M

    Market Cap

    —

    Revenue

    -$29M

    Net Income

    Employees20
    Fundamentals

    How The Business Makes Money

    Spruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for adult patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction and clinical consequences in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in Daly City, California.

    Industry Biotechnology
    Activity

    What Changed Recently

    Material Agreement
    Mar 19, 2026

    Termination of a Material Definitive Agreement. On March 16, 2026, Spruce Biosciences, Inc. (the “Company”) entered into a Termination Agreement (the “Terminati

    Management Change+3 More
    Mar 8, 2026

    Entry into a Material Definitive Agreement. On March 9, 2026, Spruce Biosciences, Inc. (the “Company”) entered into an Open Market Sale Agreement SM (the “Sales

    Regulation FD
    Feb 4, 2026

    , including Exhibit 99.1 attached hereto, is being furnished and shall not be deemed to be “filed” for the purposes of Section 18 of the Securities and Exchange

    Material Agreement+4 More
    Jan 7, 2026

    of this Current Report on Form 8-K is incorporated by reference under this Item 3.02. The securities described above will be offered and sold in reliance upon a

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    Analyst View
    Company Profile
    CIK0001683553
    ISINUS85209E2081
    CUSIP85209E208
    Phone415 655 4168
    Address2001 Junipero Serra Boulevard, Daly City, CA, 94014, US
    SEC EDGAR

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