Wave Life Sciences announced positive interim Phase 1 data from the INLIGHT trial of WVE-007, showing placebo-adjusted reductions in visceral fat (-14%; p<0.01) and waist circumference (-5.8 cm) at six months after a single 240 mg dose, with muscle preservation. The company plans to initiate the Phase 2a multidose portion in individuals with BMI 35-50 kg/m² in Q2 2026.