Jaguar Health, Inc.

Entry into a Material Definitive Agreement. Securities Purchase Agreement On January 6, 2026 (the “Execution Date”), Jaguar Health, Inc. (the “Company”) entered

in its entirety. Item 3.02 Unregistered Sales of Equity Securities. The information contained above in Item 1.01 is hereby incorporated by reference into this I

Financial Statements and Exhibits. (d) Exhibits Exhibit No. Description 4.1 Form of Unsecured Promissory Note 4.2 Form of Common Stock Warrant 10.1 Form of Secu