MLSS · Milestone Scientific Inc.

The dismissal of CBIZ CPAs and engagement of Grassi & Co. represents a significant governance and financial reporting event for Milestone Scientific Inc. The change follows CBIZ CPAs’ brief tenure—beginning in April 2025 after the Company acquired Marcum LLP’s attest business—and culminates in a 2025 audit that included a going concern qualification, signaling heightened financial risk visibility to investors. While no disagreements or reportable events were disclosed, the going concern emphasis underscores underlying liquidity or operational challenges that may affect investor confidence and future financing terms. The prompt engagement of Grassi—approved by the Audit Committee and effective May 15, 2026—suggests continuity planning, but the transition introduces execution risk around audit timing, internal control evaluation, and potential delays in future filings. CBIZ CPAs’ formal agreement with the Company’s disclosures in Exhibit 16.1 satisfies SEC requirements under Item 4.01, mitigating regulatory exposure; however, investors should monitor whether the going concern uncertainty persists in Grassi’s upcoming audit opinion and whether management discloses remediation efforts in subsequent filings.